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Conrad Wagner Selected Research

S-Adenosylmethionine (Ademetionine)

2/2016Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis.
3/2015S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease.
1/2015Associations between S-adenosylmethionine, S-adenosylhomocysteine, and colorectal adenoma risk are modified by sex.
1/2013Metabolic profiling of total homocysteine and related compounds in hyperhomocysteinemia: utility and limitations in diagnosing the cause of puzzling thrombophilia in a family.
9/2012Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.
12/2010S-adenosylhomocysteine hydrolase deficiency: two siblings with fetal hydrops and fatal outcomes.
7/2010Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide.
10/2008Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice.
12/2007S-Adenosylhomocysteine: a better indicator of vascular disease than homocysteine?
1/2007Methyl balance and transmethylation fluxes in humans.
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Conrad Wagner Research Topics

Disease

7Hypermethioninemia
02/2016 - 05/2003
4Fatty Liver
02/2016 - 04/2008
4Homocystinuria
01/2013 - 02/2002
4Hepatocellular Carcinoma (Hepatoma)
09/2012 - 04/2008
4Liver Diseases (Liver Disease)
07/2011 - 04/2008
3Non-alcoholic Fatty Liver Disease
02/2016 - 09/2010
3Hyperhomocysteinemia
01/2013 - 05/2003
3Fibrosis (Cirrhosis)
09/2012 - 04/2008
3Vascular Diseases (Vascular Disease)
01/2008 - 12/2007
2Colorectal Neoplasms (Colorectal Cancer)
11/2014 - 03/2009
2Renal Insufficiency (Renal Failure)
02/2012 - 02/2006
2Prostatic Neoplasms (Prostate Cancer)
02/2011 - 01/2011
2Inflammation (Inflammations)
09/2010 - 07/2010
2Inborn Genetic Diseases (Disease, Hereditary)
03/2004 - 06/2002
2Brain Edema (Cerebral Edema)
05/2003 - 02/2002
1Microcephaly
09/2015
1Muscular Diseases (Myopathy)
09/2015
1Factor VII Deficiency (Hypoproconvertinemia)
09/2015
1Adenoma (Adenomas)
01/2015
1Thrombophilia
01/2013
1Hepatitis
08/2012
1Hypersensitivity (Allergy)
08/2012
1Hydrops Fetalis (Fetal Edema)
12/2010
1Hypoalbuminemia
12/2010
1Chronic Pancreatitis
11/2010
1Endotoxemia
10/2008
1Liver Neoplasms (Liver Cancer)
04/2008
1Neoplasms (Cancer)
04/2008
1Brain Diseases (Brain Disorder)
06/2007
1Cardiovascular Diseases (Cardiovascular Disease)
02/2006
1Methylmalonic acidemia
04/2005
1Muscle Hypotonia (Hypotonia)
03/2004
1Teratogenesis
11/2003
1Alzheimer Disease (Alzheimer's Disease)
06/2002
1Thrombosis (Thrombus)
02/2002

Drug/Important Bio-Agent (IBA)

13Methionine (L-Methionine)FDA Link
02/2016 - 02/2002
11S-Adenosylmethionine (Ademetionine)IBA
02/2016 - 05/2003
7HomocysteineIBA
01/2013 - 02/2002
6Glycine N-Methyltransferase (Glycine Sarcosine N-Methyltransferase)IBA
02/2016 - 04/2008
6S-AdenosylhomocysteineIBA
01/2015 - 12/2007
6Folic Acid (Vitamin M)FDA LinkGeneric
11/2014 - 05/2005
3CystathionineIBA
08/2015 - 05/2003
3Cystathionine beta-Synthase (Serine Sulfhydrase)IBA
01/2013 - 02/2002
3Transaminases (Aminotransferases)IBA
12/2010 - 03/2004
3Indicators and Reagents (Reagents)IBA
12/2007 - 02/2006
2LipidsIBA
02/2016 - 03/2015
2AdenosylhomocysteinaseIBA
09/2015 - 12/2010
2Proteins (Proteins, Gene)FDA Link
03/2015 - 10/2013
2VitaminsIBA
11/2014 - 01/2013
2CreatineIBA
09/2010 - 04/2005
2EnzymesIBA
07/2010 - 04/2008
2MethyltransferasesIBA
07/2010 - 12/2007
1VLDL LipoproteinsIBA
03/2015
1Cysteine (L-Cysteine)FDA Link
01/2013
1Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric
01/2013
1Pyridoxine (Pyridoxin)FDA LinkGeneric
01/2013
1Calcium-Calmodulin-Dependent Protein Kinase KinaseIBA
09/2012
1Peptides (Polypeptides)IBA
09/2012
1Phosphotransferases (Kinase)IBA
09/2012
1Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
09/2012
1Protein Kinases (Protein Kinase)IBA
09/2012
1Ribosomal Protein S6 Kinases (S6 Kinase)IBA
09/2012
1Mitogen-Activated Protein Kinase 1 (p42 MAP Kinase)IBA
09/2012
1Adenosine (Adenocard)FDA LinkGeneric
09/2012
1Concanavalin AIBA
08/2012
1TransferasesIBA
07/2011
1Sarcosine (Methylglycine)IBA
02/2011
1Methionine AdenosyltransferaseIBA
10/2010
1EicosanoidsIBA
09/2010
1Biomarkers (Surrogate Marker)IBA
09/2010
1DNA (Deoxyribonucleic Acid)IBA
07/2010
1Fatty Acids (Saturated Fatty Acids)IBA
07/2010
1Niacinamide (Nicotinamide)FDA LinkGeneric
07/2010
1Vitamin B Complex (B Vitamins)IBA
03/2009
1Messenger RNA (mRNA)IBA
04/2008
1CytokinesIBA
04/2008
1Janus KinasesIBA
04/2008
1Oxidoreductases (Dehydrogenase)IBA
06/2007
15,10-methylenetetrahydrofolic acidIBA
06/2007
1Guanidinoacetate N-Methyltransferase (Guanidinoacetate Methyltransferase)IBA
01/2007
1Phosphatidylethanolamine N-MethyltransferaseIBA
01/2007
1Creatine Kinase (Creatine Phosphokinase)IBA
03/2004
1AlbuminsIBA
03/2004
1Tyrosine (L-Tyrosine)FDA Link
03/2004
1RetinoidsIBA
11/2003
1Adenosine Triphosphatases (ATPase)IBA
05/2003
1Protein HydrolysatesFDA Link
05/2003
1Glucose (Dextrose)FDA LinkGeneric
05/2003
1Betaine (C.B.B.)FDA Link
02/2002

Therapy/Procedure

3Therapeutics
01/2013 - 02/2002
2Liver Transplantation
09/2015 - 02/2012
1Prostatectomy (Retropubic Prostatectomy)
01/2011